Seamless correction of beta-thalassemia mutations in iPSCs using #CRISPR and piggyBac transposon.

Efficient genome editing in human cells for therapeutic purposes will continue to be one of the most anticipated uses of CRISPR.  Here's a new, good example of this direction, from Genome Research.   

Seamless gene correction of β-thalassemia mutations inpatient-specific iPSCs using CRISPR/Cas9 and piggyBac.

Fei Xie, Lin Ye, Judy C. Chang, et al.

Genome Res. published online August 5, 2014