COSMID is described in a new publication by T.J. Cradick, et al. COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites, Molecular Therapy—Nucleic Acids (2014) 3, e214. I've only used it briefly so far but it has a nice interface that allows the user to search for OTs with a user-specified max number of mismatches in combination with single-base insertions and/or deletions. It also can perform PCR primer design for the OTs with the primers optimized for Surveyor-style mutation screening. Thanks go to T.J. and colleagues for the nice addition to the CRISPR off-target screening toolkit.
Alas, this already raises a new caveat about my previous post reviewing off-targets in mice: I'm pretty sure that most or all of those citations did not look at indel OTs, only mismatch OTs. !